p62 links autophagy and Nrf2 signaling

autophagy pathway p62  In addition, p62SQSTM1 functions as a selective autophagy receptor for degradation of ubiqutinated substrates In the present review, we Degraders exemplified by proteolysis-targeting chimeras hijack the ubiquitin–proteasome pathway and evoke target-specific

Phospho-p62 with bound Keap1 interacts with LC3 through the LIR and is degraded by the autophagy pathway Thus, the cells under This review focuses on the role of p62 in linking the ubiquitin–proteasome system and autophagy pathway upon ubiquitinated protein degradation

p62 was well known to act as a scaffold protein in signaling pathways involving NF-κB , but to also accumulate in ubiquitin The removal of abnormal proteins is primarily done by the ubiquitin–proteasome system , the major protein degradation pathway in the cell